منابع مشابه
Malaria transmission and naturally acquired immunity to PfEMP-1.
Why there are so few gametocytes (the transmission stage of malaria) in the blood of humans infected with Plasmodium spp. is intriguing. This may be due either to reproductive restraint by the parasite or to unidentified gametocyte-specific immune-mediated clearance mechanisms. We propose another mechanism, a cross-stage immunity to Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP-1)...
متن کاملAcquired immunity to malaria.
Naturally acquired immunity to falciparum malaria protects millions of people routinely exposed to Plasmodium falciparum infection from severe disease and death. There is no clear concept about how this protection works. There is no general agreement about the rate of onset of acquired immunity or what constitutes the key determinants of protection; much less is there a consensus regarding the ...
متن کاملNaturally acquired immunity to tetanus toxin in an isolated community.
Literature on natural immunity to tetanus is scarce. We examined antitetanus antibody levels with the enzyme-linked immunosorbent assay in 200 people living in an isolated community and clarified the influence of age and sex on immunity. In 197 subjects, antitoxin antibodies were measured. No sex differences were noted, and 30% had protective levels (above 0.01 IU/ml). The percentage of those c...
متن کاملThe Dynamics of Naturally Acquired Immunity to Plasmodium falciparum Infection
Severe malaria occurs predominantly in young children and immunity to clinical disease is associated with cumulative exposure in holoendemic settings. The relative contribution of immunity against various stages of the parasite life cycle that results in controlling infection and limiting disease is not well understood. Here we analyse the dynamics of Plasmodium falciparum malaria infection aft...
متن کاملNaturally Acquired Antibody Responses to a Synthetic Malaria Antigen AS202.11
Background A major challenge to malaria vaccine development is identification of protective epitopes and respective protective immune responses. Objective To characterize naturally acquired Immunoglobulin G (IgG) responses to the synthetic peptide AS202.11, a malaria vaccine candidate. Methodology This community based cross-sectional study enrolled 320 participants aged 1 year and above. De...
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ژورنال
عنوان ژورنال: Parasitology
سال: 2016
ISSN: 0031-1820,1469-8161
DOI: 10.1017/s0031182015001778